EGFR

ENSG00000146648 - H. sapiens

Pathways

Go term Description
GO:0001948 glycoprotein binding
GO:0003682 chromatin binding
GO:0003690 double-stranded DNA binding
GO:0004709 MAP kinase kinase kinase activity
GO:0004713 protein tyrosine kinase activity
GO:0004714 transmembrane receptor protein tyrosine kinase activity
GO:0004716 signal transducer, downstream of receptor, with protein tyrosine kinase activity
GO:0004888 transmembrane signaling receptor activity
GO:0005006 epidermal growth factor-activated receptor activity
GO:0005088 Ras guanyl-nucleotide exchange factor activity
GO:0005178 integrin binding
GO:0005515 protein binding
GO:0005516 calmodulin binding
GO:0005524 ATP binding
GO:0019899 enzyme binding
GO:0019901 protein kinase binding
GO:0019903 protein phosphatase binding
GO:0031625 ubiquitin protein ligase binding
GO:0042802 identical protein binding
GO:0046934 phosphatidylinositol-4,5-bisphosphate 3-kinase activity
GO:0046982 protein heterodimerization activity
GO:0048408 epidermal growth factor binding
GO:0051015 actin filament binding
GO:0098641 cadherin binding involved in cell-cell adhesion
GO:0030235 nitric-oxide synthase regulator activity
GO:0019904 protein domain specific binding

Drugs

Drug name Description
AFATINIB Epidermal growth factor receptor erbB1 inhibitor
CETUXIMAB Epidermal growth factor receptor erbB1 inhibitor
ERLOTINIB Epidermal growth factor receptor erbB1 inhibitor
GEFITINIB Epidermal growth factor receptor erbB1 inhibitor
LAPATINIB Epidermal growth factor receptor erbB1 inhibitor
PANITUMUMAB Epidermal growth factor receptor erbB1 inhibitor
VANDETANIB Epidermal growth factor receptor inhibitor

Diseases

Disease Name
glioma
NSCLC

Orthologs

Gene Organism
let-23 C. elegans
Egfr D. melanogaster

Related Interactions

Gene ID A Gene Name A Gene ID B Gene Symbol B Organism Source Score?
ENSG00000146648 EGFR ENSG00000166501 PRKCB H. sapiens SDL Slorth 0.982017 View
ENSG00000126858 RHOT1 ENSG00000146648 EGFR H. sapiens SDL Slorth 0.982006 View
ENSG00000137265 IRF4 ENSG00000146648 EGFR H. sapiens SDL Slorth 0.982003 View
ENSG00000011007 TCEB3 ENSG00000146648 EGFR H. sapiens SDL Slorth 0.981998 View
ENSG00000146648 EGFR ENSG00000163602 RYBP H. sapiens SDL Slorth 0.981982 View
ENSG00000123094 RASSF8 ENSG00000146648 EGFR H. sapiens SDL Slorth 0.981961 View
ENSG00000125834 STK35 ENSG00000146648 EGFR H. sapiens SDL Slorth 0.981956 View
ENSG00000146648 EGFR ENSG00000197451 HNRNPAB H. sapiens SDL Slorth 0.981941 View
ENSG00000116990 MYCL ENSG00000146648 EGFR H. sapiens SDL Slorth 0.981916 View
ENSG00000128881 TTBK2 ENSG00000146648 EGFR H. sapiens SDL Slorth 0.981889 View
ENSG00000146648 EGFR ENSG00000155511 GRIA1 H. sapiens SDL Slorth 0.981865 View
ENSG00000146648 EGFR ENSG00000198561 CTNND1 H. sapiens SDL Slorth 0.981821 View
ENSG00000128513 POT1 ENSG00000146648 EGFR H. sapiens SDL Slorth 0.981821 View
ENSG00000088367 EPB41L1 ENSG00000146648 EGFR H. sapiens SDL Slorth 0.981817 View
ENSG00000140199 SLC12A6 ENSG00000146648 EGFR H. sapiens SDL Slorth 0.9818 View
ENSG00000146648 EGFR ENSG00000159259 CHAF1B H. sapiens SDL Slorth 0.98178 View
ENSG00000124207 CSE1L ENSG00000146648 EGFR H. sapiens SDL Slorth 0.981762 View
ENSG00000146648 EGFR ENSG00000183955 KMT5A H. sapiens SDL Slorth 0.981758 View
ENSG00000116574 RHOU ENSG00000146648 EGFR H. sapiens SDL Slorth 0.981747 View
ENSG00000115963 RND3 ENSG00000146648 EGFR H. sapiens SDL Slorth 0.981702 View
ENSG00000146648 EGFR ENSG00000180353 HCLS1 H. sapiens SDL Slorth 0.98168 View
ENSG00000146648 EGFR ENSG00000182968 SOX1 H. sapiens SDL Slorth 0.981673 View
ENSG00000146648 EGFR ENSG00000160867 FGFR4 H. sapiens SDL Slorth 0.981553 View
ENSG00000146648 EGFR ENSG00000175376 EIF1AD H. sapiens SDL Slorth 0.98155 View
ENSG00000146648 EGFR ENSG00000166592 RRAD H. sapiens SDL Slorth 0.981528 View
ENSG00000146648 EGFR ENSG00000171608 PIK3CD H. sapiens SDL Slorth 0.981519 View
ENSG00000146648 EGFR ENSG00000149084 HSD17B12 H. sapiens SDL Slorth 0.981507 View
ENSG00000111218 PRMT8 ENSG00000146648 EGFR H. sapiens SDL Slorth 0.981499 View
ENSG00000135776 ABCB10 ENSG00000146648 EGFR H. sapiens SDL Slorth 0.98149 View
ENSG00000124782 RREB1 ENSG00000146648 EGFR H. sapiens SDL Slorth 0.981474 View
ENSG00000123600 METTL8 ENSG00000146648 EGFR H. sapiens SDL Slorth 0.981469 View
ENSG00000146648 EGFR ENSG00000188996 HUS1B H. sapiens SDL Slorth 0.981463 View
ENSG00000146648 EGFR ENSG00000184012 TMPRSS2 H. sapiens SDL Slorth 0.981416 View
ENSG00000146648 EGFR ENSG00000184840 TMED9 H. sapiens SDL Slorth 0.9814 View
ENSG00000131437 KIF3A ENSG00000146648 EGFR H. sapiens SDL Slorth 0.981391 View
ENSG00000130589 HELZ2 ENSG00000146648 EGFR H. sapiens SDL Slorth 0.981389 View
ENSG00000117318 ID3 ENSG00000146648 EGFR H. sapiens SDL Slorth 0.981364 View
ENSG00000115993 TRAK2 ENSG00000146648 EGFR H. sapiens SDL Slorth 0.981363 View
ENSG00000146648 EGFR ENSG00000198873 GRK5 H. sapiens SDL Slorth 0.981363 View
ENSG00000146648 EGFR ENSG00000185122 HSF1 H. sapiens SDL Slorth 0.981282 View