EGFR

ENSG00000146648 - H. sapiens

Pathways

Go term Description
GO:0001948 glycoprotein binding
GO:0003682 chromatin binding
GO:0003690 double-stranded DNA binding
GO:0004709 MAP kinase kinase kinase activity
GO:0004713 protein tyrosine kinase activity
GO:0004714 transmembrane receptor protein tyrosine kinase activity
GO:0004716 signal transducer, downstream of receptor, with protein tyrosine kinase activity
GO:0004888 transmembrane signaling receptor activity
GO:0005006 epidermal growth factor-activated receptor activity
GO:0005088 Ras guanyl-nucleotide exchange factor activity
GO:0005178 integrin binding
GO:0005515 protein binding
GO:0005516 calmodulin binding
GO:0005524 ATP binding
GO:0019899 enzyme binding
GO:0019901 protein kinase binding
GO:0019903 protein phosphatase binding
GO:0031625 ubiquitin protein ligase binding
GO:0042802 identical protein binding
GO:0046934 phosphatidylinositol-4,5-bisphosphate 3-kinase activity
GO:0046982 protein heterodimerization activity
GO:0048408 epidermal growth factor binding
GO:0051015 actin filament binding
GO:0098641 cadherin binding involved in cell-cell adhesion
GO:0030235 nitric-oxide synthase regulator activity
GO:0019904 protein domain specific binding

Drugs

Drug name Description
AFATINIB Epidermal growth factor receptor erbB1 inhibitor
CETUXIMAB Epidermal growth factor receptor erbB1 inhibitor
ERLOTINIB Epidermal growth factor receptor erbB1 inhibitor
GEFITINIB Epidermal growth factor receptor erbB1 inhibitor
LAPATINIB Epidermal growth factor receptor erbB1 inhibitor
PANITUMUMAB Epidermal growth factor receptor erbB1 inhibitor
VANDETANIB Epidermal growth factor receptor inhibitor

Diseases

Disease Name
glioma
NSCLC

Orthologs

Gene Organism
let-23 C. elegans
Egfr D. melanogaster

Related Interactions

Gene ID A Gene Name A Gene ID B Gene Symbol B Organism Source Score?
ENSG00000143294 PRCC ENSG00000146648 EGFR H. sapiens SDL Slorth 0.984185 View
ENSG00000146648 EGFR ENSG00000183020 AP2A2 H. sapiens SDL Slorth 0.984179 View
ENSG00000146648 EGFR ENSG00000147010 SH3KBP1 H. sapiens SDL Slorth 0.984153 View
ENSG00000104892 KLC3 ENSG00000146648 EGFR H. sapiens SDL Slorth 0.984132 View
ENSG00000117625 RCOR3 ENSG00000146648 EGFR H. sapiens SDL Slorth 0.984109 View
ENSG00000129354 AP1M2 ENSG00000146648 EGFR H. sapiens SDL Slorth 0.984099 View
ENSG00000146648 EGFR ENSG00000160789 LMNA H. sapiens SDL Slorth 0.984078 View
ENSG00000146648 EGFR ENSG00000175354 PTPN2 H. sapiens SDL Slorth 0.983973 View
ENSG00000146648 EGFR ENSG00000169750 RAC3 H. sapiens SDL Slorth 0.98397 View
ENSG00000146648 EGFR ENSG00000186153 WWOX H. sapiens SDL Slorth 0.983938 View
ENSG00000070444 MNT ENSG00000146648 EGFR H. sapiens SDL Slorth 0.983917 View
ENSG00000146648 EGFR ENSG00000174738 NR1D2 H. sapiens SDL Slorth 0.983911 View
ENSG00000146648 EGFR ENSG00000177105 RHOG H. sapiens SDL Slorth 0.983907 View
ENSG00000135604 STX11 ENSG00000146648 EGFR H. sapiens SDL Slorth 0.983891 View
ENSG00000146648 EGFR ENSG00000155974 GRIP1 H. sapiens SDL Slorth 0.983889 View
ENSG00000143514 TP53BP2 ENSG00000146648 EGFR H. sapiens SDL Slorth 0.983862 View
ENSG00000124209 RAB22A ENSG00000146648 EGFR H. sapiens SDL Slorth 0.983856 View
ENSG00000086827 ZW10 ENSG00000146648 EGFR H. sapiens SDL Slorth 0.983818 View
ENSG00000109519 GRPEL1 ENSG00000146648 EGFR H. sapiens SDL Slorth 0.983795 View
ENSG00000146648 EGFR ENSG00000184675 AMER1 H. sapiens SDL Slorth 0.983791 View
ENSG00000102317 RBM3 ENSG00000146648 EGFR H. sapiens SDL Slorth 0.983783 View
ENSG00000105612 DNASE2 ENSG00000146648 EGFR H. sapiens SDL Slorth 0.983726 View
ENSG00000076067 RBMS2 ENSG00000146648 EGFR H. sapiens SDL Slorth 0.983712 View
ENSG00000146648 EGFR ENSG00000168959 GRM5 H. sapiens SDL Slorth 0.9837 View
ENSG00000107282 APBA1 ENSG00000146648 EGFR H. sapiens SDL Slorth 0.983645 View
ENSG00000095397 WHRN ENSG00000146648 EGFR H. sapiens SDL Slorth 0.983643 View
ENSG00000077684 JADE1 ENSG00000146648 EGFR H. sapiens SDL Slorth 0.983617 View
ENSG00000078403 MLLT10 ENSG00000146648 EGFR H. sapiens SDL Slorth 0.983575 View
ENSG00000146648 EGFR ENSG00000188191 PRKAR1B H. sapiens SDL Slorth 0.983544 View
ENSG00000146648 EGFR ENSG00000184702 SEPT5 H. sapiens SDL Slorth 0.983508 View
ENSG00000144935 TRPC1 ENSG00000146648 EGFR H. sapiens SDL Slorth 0.983488 View
ENSG00000146648 EGFR ENSG00000175634 RPS6KB2 H. sapiens SDL Slorth 0.98348 View
ENSG00000139626 ITGB7 ENSG00000146648 EGFR H. sapiens SDL Slorth 0.983476 View
ENSG00000126785 RHOJ ENSG00000146648 EGFR H. sapiens SDL Slorth 0.983409 View
ENSG00000146648 EGFR ENSG00000162302 RPS6KA4 H. sapiens SDL Slorth 0.983409 View
ENSG00000146648 EGFR ENSG00000186716 BCR H. sapiens SDL Slorth 0.983405 View
ENSG00000146648 EGFR ENSG00000169926 KLF13 H. sapiens SDL Slorth 0.983396 View
ENSG00000146648 EGFR ENSG00000151491 EPS8 H. sapiens SDL Slorth 0.98338 View
ENSG00000049323 LTBP1 ENSG00000146648 EGFR H. sapiens SDL Slorth 0.983364 View
ENSG00000141084 RANBP10 ENSG00000146648 EGFR H. sapiens SDL Slorth 0.983341 View