EGFR

ENSG00000146648 - H. sapiens

Pathways

Go term Description
GO:0001948 glycoprotein binding
GO:0003682 chromatin binding
GO:0003690 double-stranded DNA binding
GO:0004709 MAP kinase kinase kinase activity
GO:0004713 protein tyrosine kinase activity
GO:0004714 transmembrane receptor protein tyrosine kinase activity
GO:0004716 signal transducer, downstream of receptor, with protein tyrosine kinase activity
GO:0004888 transmembrane signaling receptor activity
GO:0005006 epidermal growth factor-activated receptor activity
GO:0005088 Ras guanyl-nucleotide exchange factor activity
GO:0005178 integrin binding
GO:0005515 protein binding
GO:0005516 calmodulin binding
GO:0005524 ATP binding
GO:0019899 enzyme binding
GO:0019901 protein kinase binding
GO:0019903 protein phosphatase binding
GO:0031625 ubiquitin protein ligase binding
GO:0042802 identical protein binding
GO:0046934 phosphatidylinositol-4,5-bisphosphate 3-kinase activity
GO:0046982 protein heterodimerization activity
GO:0048408 epidermal growth factor binding
GO:0051015 actin filament binding
GO:0098641 cadherin binding involved in cell-cell adhesion
GO:0030235 nitric-oxide synthase regulator activity
GO:0019904 protein domain specific binding

Drugs

Drug name Description
AFATINIB Epidermal growth factor receptor erbB1 inhibitor
CETUXIMAB Epidermal growth factor receptor erbB1 inhibitor
ERLOTINIB Epidermal growth factor receptor erbB1 inhibitor
GEFITINIB Epidermal growth factor receptor erbB1 inhibitor
LAPATINIB Epidermal growth factor receptor erbB1 inhibitor
PANITUMUMAB Epidermal growth factor receptor erbB1 inhibitor
VANDETANIB Epidermal growth factor receptor inhibitor

Diseases

Disease Name
glioma
NSCLC

Orthologs

Gene Organism
let-23 C. elegans
Egfr D. melanogaster

Related Interactions

Gene ID A Gene Name A Gene ID B Gene Symbol B Organism Source Score?
ENSG00000139546 TARBP2 ENSG00000146648 EGFR H. sapiens SDL Slorth 0.9808 View
ENSG00000131791 PRKAB2 ENSG00000146648 EGFR H. sapiens SDL Slorth 0.980795 View
ENSG00000146648 EGFR ENSG00000184481 FOXO4 H. sapiens SDL Slorth 0.980754 View
ENSG00000146648 EGFR ENSG00000166224 SGPL1 H. sapiens SDL Slorth 0.980738 View
ENSG00000146648 EGFR ENSG00000148660 CAMK2G H. sapiens SDL Slorth 0.980725 View
ENSG00000057608 GDI2 ENSG00000146648 EGFR H. sapiens SDL Slorth 0.980716 View
ENSG00000128731 HERC2 ENSG00000146648 EGFR H. sapiens SDL Slorth 0.980693 View
ENSG00000146648 EGFR ENSG00000180176 TH H. sapiens SDL Slorth 0.980691 View
ENSG00000131381 RBSN ENSG00000146648 EGFR H. sapiens SDL Slorth 0.980679 View
ENSG00000134014 ELP3 ENSG00000146648 EGFR H. sapiens SDL Slorth 0.980675 View
ENSG00000041353 RAB27B ENSG00000146648 EGFR H. sapiens SDL Slorth 0.980664 View
ENSG00000067141 NEO1 ENSG00000146648 EGFR H. sapiens SDL Slorth 0.980664 View
ENSG00000123612 ACVR1C ENSG00000146648 EGFR H. sapiens SDL Slorth 0.980664 View
ENSG00000100823 APEX1 ENSG00000146648 EGFR H. sapiens SDL Slorth 0.980617 View
ENSG00000121957 GPSM2 ENSG00000146648 EGFR H. sapiens SDL Slorth 0.980615 View
ENSG00000146648 EGFR ENSG00000148737 TCF7L2 H. sapiens SDL Slorth 0.98061 View
ENSG00000146648 EGFR ENSG00000154016 GRAP H. sapiens SDL Slorth 0.98058 View
ENSG00000007237 GAS7 ENSG00000146648 EGFR H. sapiens SDL Slorth 0.980569 View
ENSG00000007312 CD79B ENSG00000146648 EGFR H. sapiens SDL Slorth 0.980528 View
ENSG00000146648 EGFR ENSG00000163655 GMPS H. sapiens SDL Slorth 0.980515 View
ENSG00000145555 MYO10 ENSG00000146648 EGFR H. sapiens SDL Slorth 0.980493 View
ENSG00000146648 EGFR ENSG00000157404 KIT H. sapiens SDL Slorth 0.980486 View
ENSG00000146648 EGFR ENSG00000164548 TRA2A H. sapiens SDL Slorth 0.980452 View
ENSG00000127955 GNAI1 ENSG00000146648 EGFR H. sapiens SDL Slorth 0.980446 View
ENSG00000134686 PHC2 ENSG00000146648 EGFR H. sapiens SDL Slorth 0.980443 View
ENSG00000136750 GAD2 ENSG00000146648 EGFR H. sapiens SDL Slorth 0.980432 View
ENSG00000138613 APH1B ENSG00000146648 EGFR H. sapiens SDL Slorth 0.980414 View
ENSG00000146648 EGFR ENSG00000177084 POLE H. sapiens SDL Slorth 0.980404 View
ENSG00000127314 RAP1B ENSG00000146648 EGFR H. sapiens SDL Slorth 0.980402 View
ENSG00000137166 FOXP4 ENSG00000146648 EGFR H. sapiens SDL Slorth 0.980385 View
ENSG00000138594 TMOD3 ENSG00000146648 EGFR H. sapiens SDL Slorth 0.980385 View
ENSG00000090889 KIF4A ENSG00000146648 EGFR H. sapiens SDL Slorth 0.980378 View
ENSG00000138674 SEC31A ENSG00000146648 EGFR H. sapiens SDL Slorth 0.980352 View
ENSG00000082641 NFE2L1 ENSG00000146648 EGFR H. sapiens SDL Slorth 0.980308 View
ENSG00000087085 ACHE ENSG00000146648 EGFR H. sapiens SDL Slorth 0.980295 View
ENSG00000146648 EGFR ENSG00000147140 NONO H. sapiens SDL Slorth 0.980292 View
ENSG00000146648 EGFR ENSG00000171105 INSR H. sapiens SDL Slorth 0.980281 View
ENSG00000146648 EGFR ENSG00000163132 MSX1 H. sapiens SDL Slorth 0.980265 View
ENSG00000143171 RXRG ENSG00000146648 EGFR H. sapiens SDL Slorth 0.980259 View
ENSG00000115685 PPP1R7 ENSG00000146648 EGFR H. sapiens SDL Slorth 0.98023 View