EGFR

ENSG00000146648 - H. sapiens

Pathways

Go term Description
GO:0001948 glycoprotein binding
GO:0003682 chromatin binding
GO:0003690 double-stranded DNA binding
GO:0004709 MAP kinase kinase kinase activity
GO:0004713 protein tyrosine kinase activity
GO:0004714 transmembrane receptor protein tyrosine kinase activity
GO:0004716 signal transducer, downstream of receptor, with protein tyrosine kinase activity
GO:0004888 transmembrane signaling receptor activity
GO:0005006 epidermal growth factor-activated receptor activity
GO:0005088 Ras guanyl-nucleotide exchange factor activity
GO:0005178 integrin binding
GO:0005515 protein binding
GO:0005516 calmodulin binding
GO:0005524 ATP binding
GO:0019899 enzyme binding
GO:0019901 protein kinase binding
GO:0019903 protein phosphatase binding
GO:0031625 ubiquitin protein ligase binding
GO:0042802 identical protein binding
GO:0046934 phosphatidylinositol-4,5-bisphosphate 3-kinase activity
GO:0046982 protein heterodimerization activity
GO:0048408 epidermal growth factor binding
GO:0051015 actin filament binding
GO:0098641 cadherin binding involved in cell-cell adhesion
GO:0030235 nitric-oxide synthase regulator activity
GO:0019904 protein domain specific binding

Drugs

Drug name Description
AFATINIB Epidermal growth factor receptor erbB1 inhibitor
CETUXIMAB Epidermal growth factor receptor erbB1 inhibitor
ERLOTINIB Epidermal growth factor receptor erbB1 inhibitor
GEFITINIB Epidermal growth factor receptor erbB1 inhibitor
LAPATINIB Epidermal growth factor receptor erbB1 inhibitor
PANITUMUMAB Epidermal growth factor receptor erbB1 inhibitor
VANDETANIB Epidermal growth factor receptor inhibitor

Diseases

Disease Name
glioma
NSCLC

Orthologs

Gene Organism
let-23 C. elegans
Egfr D. melanogaster

Related Interactions

Gene ID A Gene Name A Gene ID B Gene Symbol B Organism Source Score?
ENSG00000146648 EGFR ENSG00000178184 PARD6G H. sapiens SDL Slorth 0.977294 View
ENSG00000083857 FAT1 ENSG00000146648 EGFR H. sapiens SDL Slorth 0.977268 View
ENSG00000092847 AGO1 ENSG00000146648 EGFR H. sapiens SDL Slorth 0.977267 View
ENSG00000140678 ITGAX ENSG00000146648 EGFR H. sapiens SDL Slorth 0.977245 View
ENSG00000146648 EGFR ENSG00000186575 NF2 H. sapiens SDL Slorth 0.977245 View
ENSG00000146648 EGFR ENSG00000184432 COPB2 H. sapiens SDL Slorth 0.977235 View
ENSG00000111664 GNB3 ENSG00000146648 EGFR H. sapiens SDL Slorth 0.977231 View
ENSG00000113328 CCNG1 ENSG00000146648 EGFR H. sapiens SDL Slorth 0.977217 View
ENSG00000044115 CTNNA1 ENSG00000146648 EGFR H. sapiens SDL Slorth 0.977216 View
ENSG00000077279 DCX ENSG00000146648 EGFR H. sapiens SDL Slorth 0.977215 View
ENSG00000112186 CAP2 ENSG00000146648 EGFR H. sapiens SDL Slorth 0.977211 View
ENSG00000146648 EGFR ENSG00000149503 INCENP H. sapiens SDL Slorth 0.977211 View
ENSG00000100077 GRK3 ENSG00000146648 EGFR H. sapiens SDL Slorth 0.97721 View
ENSG00000124795 DEK ENSG00000146648 EGFR H. sapiens SDL Slorth 0.97721 View
ENSG00000146648 EGFR ENSG00000160007 ARHGAP35 H. sapiens SDL Slorth 0.977188 View
ENSG00000146648 EGFR ENSG00000152284 TCF7L1 H. sapiens SDL Slorth 0.977146 View
ENSG00000146648 EGFR ENSG00000183072 NKX2-5 H. sapiens SDL Slorth 0.977145 View
ENSG00000146648 EGFR ENSG00000154928 EPHB1 H. sapiens SDL Slorth 0.977135 View
ENSG00000051108 HERPUD1 ENSG00000146648 EGFR H. sapiens SDL Slorth 0.977135 View
ENSG00000101255 TRIB3 ENSG00000146648 EGFR H. sapiens SDL Slorth 0.977135 View
ENSG00000100092 SH3BP1 ENSG00000146648 EGFR H. sapiens SDL Slorth 0.977135 View
ENSG00000146648 EGFR ENSG00000198677 TTC37 H. sapiens SDL Slorth 0.977131 View
ENSG00000146648 EGFR ENSG00000181090 EHMT1 H. sapiens SDL Slorth 0.977122 View
ENSG00000123405 NFE2 ENSG00000146648 EGFR H. sapiens SDL Slorth 0.977107 View
ENSG00000146648 EGFR ENSG00000163840 DTX3L H. sapiens SDL Slorth 0.977106 View
ENSG00000112679 DUSP22 ENSG00000146648 EGFR H. sapiens SDL Slorth 0.977095 View
ENSG00000122966 CIT ENSG00000146648 EGFR H. sapiens SDL Slorth 0.977083 View
ENSG00000095794 CREM ENSG00000146648 EGFR H. sapiens SDL Slorth 0.977081 View
ENSG00000146648 EGFR ENSG00000155660 PDIA4 H. sapiens SDL Slorth 0.977076 View
ENSG00000146648 EGFR ENSG00000171094 ALK H. sapiens SDL Slorth 0.977071 View
ENSG00000011485 PPP5C ENSG00000146648 EGFR H. sapiens SDL Slorth 0.977069 View
ENSG00000110148 CCKBR ENSG00000146648 EGFR H. sapiens SDL Slorth 0.977065 View
ENSG00000100417 PMM1 ENSG00000146648 EGFR H. sapiens SDL Slorth 0.97706 View
ENSG00000071575 TRIB2 ENSG00000146648 EGFR H. sapiens SDL Slorth 0.977057 View
ENSG00000012983 MAP4K5 ENSG00000146648 EGFR H. sapiens SDL Slorth 0.977051 View
ENSG00000067900 ROCK1 ENSG00000146648 EGFR H. sapiens SDL Slorth 0.977042 View
ENSG00000146648 EGFR ENSG00000154710 RABGEF1 H. sapiens SDL Slorth 0.97703 View
ENSG00000135723 FHOD1 ENSG00000146648 EGFR H. sapiens SDL Slorth 0.977001 View
ENSG00000140538 NTRK3 ENSG00000146648 EGFR H. sapiens SDL Slorth 0.976999 View
ENSG00000146648 EGFR ENSG00000148484 RSU1 H. sapiens SDL Slorth 0.976981 View