EGFR

ENSG00000146648 - H. sapiens

Pathways

Go term Description
GO:0001948 glycoprotein binding
GO:0003682 chromatin binding
GO:0003690 double-stranded DNA binding
GO:0004709 MAP kinase kinase kinase activity
GO:0004713 protein tyrosine kinase activity
GO:0004714 transmembrane receptor protein tyrosine kinase activity
GO:0004716 signal transducer, downstream of receptor, with protein tyrosine kinase activity
GO:0004888 transmembrane signaling receptor activity
GO:0005006 epidermal growth factor-activated receptor activity
GO:0005088 Ras guanyl-nucleotide exchange factor activity
GO:0005178 integrin binding
GO:0005515 protein binding
GO:0005516 calmodulin binding
GO:0005524 ATP binding
GO:0019899 enzyme binding
GO:0019901 protein kinase binding
GO:0019903 protein phosphatase binding
GO:0031625 ubiquitin protein ligase binding
GO:0042802 identical protein binding
GO:0046934 phosphatidylinositol-4,5-bisphosphate 3-kinase activity
GO:0046982 protein heterodimerization activity
GO:0048408 epidermal growth factor binding
GO:0051015 actin filament binding
GO:0098641 cadherin binding involved in cell-cell adhesion
GO:0030235 nitric-oxide synthase regulator activity
GO:0019904 protein domain specific binding

Drugs

Drug name Description
AFATINIB Epidermal growth factor receptor erbB1 inhibitor
CETUXIMAB Epidermal growth factor receptor erbB1 inhibitor
ERLOTINIB Epidermal growth factor receptor erbB1 inhibitor
GEFITINIB Epidermal growth factor receptor erbB1 inhibitor
LAPATINIB Epidermal growth factor receptor erbB1 inhibitor
PANITUMUMAB Epidermal growth factor receptor erbB1 inhibitor
VANDETANIB Epidermal growth factor receptor inhibitor

Diseases

Disease Name
glioma
NSCLC

Orthologs

Gene Organism
let-23 C. elegans
Egfr D. melanogaster

Related Interactions

Gene ID A Gene Name A Gene ID B Gene Symbol B Organism Source Score?
ENSG00000146648 EGFR ENSG00000154310 TNIK H. sapiens SDL Slorth 0.978319 View
ENSG00000106459 NRF1 ENSG00000146648 EGFR H. sapiens SDL Slorth 0.978305 View
ENSG00000146648 EGFR ENSG00000175197 DDIT3 H. sapiens SDL Slorth 0.978279 View
ENSG00000096696 DSP ENSG00000146648 EGFR H. sapiens SDL Slorth 0.97825 View
ENSG00000007908 SELE ENSG00000146648 EGFR H. sapiens SDL Slorth 0.978222 View
ENSG00000006451 RALA ENSG00000146648 EGFR H. sapiens SDL Slorth 0.978217 View
ENSG00000017797 RALBP1 ENSG00000146648 EGFR H. sapiens SDL Slorth 0.978202 View
ENSG00000146648 EGFR ENSG00000187741 FANCA H. sapiens SDL Slorth 0.978198 View
ENSG00000100359 SGSM3 ENSG00000146648 EGFR H. sapiens SDL Slorth 0.978188 View
ENSG00000114554 PLXNA1 ENSG00000146648 EGFR H. sapiens SDL Slorth 0.978176 View
ENSG00000111049 MYF5 ENSG00000146648 EGFR H. sapiens SDL Slorth 0.978171 View
ENSG00000047849 MAP4 ENSG00000146648 EGFR H. sapiens SDL Slorth 0.978153 View
ENSG00000100084 HIRA ENSG00000146648 EGFR H. sapiens SDL Slorth 0.978134 View
ENSG00000133112 TPT1 ENSG00000146648 EGFR H. sapiens SDL Slorth 0.97811 View
ENSG00000146648 EGFR ENSG00000181789 COPG1 H. sapiens SDL Slorth 0.97811 View
ENSG00000143801 PSEN2 ENSG00000146648 EGFR H. sapiens SDL Slorth 0.978106 View
ENSG00000037757 MRI1 ENSG00000146648 EGFR H. sapiens SDL Slorth 0.978104 View
ENSG00000146648 EGFR ENSG00000205629 LCMT1 H. sapiens SDL Slorth 0.97809 View
ENSG00000072501 SMC1A ENSG00000146648 EGFR H. sapiens SDL Slorth 0.978083 View
ENSG00000126368 NR1D1 ENSG00000146648 EGFR H. sapiens SDL Slorth 0.978073 View
ENSG00000072736 NFATC3 ENSG00000146648 EGFR H. sapiens SDL Slorth 0.978023 View
ENSG00000146648 EGFR ENSG00000165699 TSC1 H. sapiens SDL Slorth 0.978022 View
ENSG00000146648 EGFR ENSG00000159251 ACTC1 H. sapiens SDL Slorth 0.977999 View
ENSG00000146648 EGFR ENSG00000169100 SLC25A6 H. sapiens SDL Slorth 0.977991 View
ENSG00000146648 EGFR ENSG00000173846 PLK3 H. sapiens SDL Slorth 0.977986 View
ENSG00000146648 EGFR ENSG00000197930 ERO1A H. sapiens SDL Slorth 0.977985 View
ENSG00000146648 EGFR ENSG00000188603 CLN3 H. sapiens SDL Slorth 0.977974 View
ENSG00000144668 ITGA9 ENSG00000146648 EGFR H. sapiens SDL Slorth 0.977973 View
ENSG00000123191 ATP7B ENSG00000146648 EGFR H. sapiens SDL Slorth 0.977968 View
ENSG00000127946 HIP1 ENSG00000146648 EGFR H. sapiens SDL Slorth 0.977938 View
ENSG00000146648 EGFR ENSG00000169252 ADRB2 H. sapiens SDL Slorth 0.97793 View
ENSG00000146648 EGFR ENSG00000248333 CDK11B H. sapiens SDL Slorth 0.977928 View
ENSG00000146648 EGFR ENSG00000159692 CTBP1 H. sapiens SDL Slorth 0.977927 View
ENSG00000123080 CDKN2C ENSG00000146648 EGFR H. sapiens SDL Slorth 0.977883 View
ENSG00000133703 KRAS ENSG00000146648 EGFR H. sapiens SDL Slorth 0.977867 View
ENSG00000146648 EGFR ENSG00000159200 RCAN1 H. sapiens SDL Slorth 0.977866 View
ENSG00000132698 RAB25 ENSG00000146648 EGFR H. sapiens SDL Slorth 0.977844 View
ENSG00000128191 DGCR8 ENSG00000146648 EGFR H. sapiens SDL Slorth 0.977844 View
ENSG00000146648 EGFR ENSG00000173933 RBM4 H. sapiens SDL Slorth 0.977814 View
ENSG00000100228 RAB36 ENSG00000146648 EGFR H. sapiens SDL Slorth 0.977811 View