MAP2K2

ENSG00000126934 - H. sapiens

Pathways

Go term Description
GO:0004674 protein serine/threonine kinase activity
GO:0004702 signal transducer, downstream of receptor, with serine/threonine kinase activity
GO:0004708 MAP kinase kinase activity
GO:0004712 protein serine/threonine/tyrosine kinase activity
GO:0004713 protein tyrosine kinase activity
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0030165 PDZ domain binding
GO:0043539 protein serine/threonine kinase activator activity
GO:0046872 metal ion binding
GO:0097110 scaffold protein binding

Drugs

Drug name Description
TRAMETINIB Dual specificity mitogen-activated protein kinase kinase 2 inhibitor

Diseases

Disease Name
NSCLC
melanoma

Orthologs

Gene Organism
PBS2 S. cerevisiae
mek-2 C. elegans
Dsor1 D. melanogaster

Related Interactions

Gene ID A Gene Name A Gene ID B Gene Symbol B Organism Source Score?
ENSG00000110713 NUP98 ENSG00000126934 MAP2K2 H. sapiens SSL Slorth 0.895348 View
ENSG00000101966 XIAP ENSG00000126934 MAP2K2 H. sapiens SSL Slorth 0.893902 View
ENSG00000105810 CDK6 ENSG00000126934 MAP2K2 H. sapiens SSL Slorth 0.89331 View
ENSG00000100030 MAPK1 ENSG00000126934 MAP2K2 H. sapiens SSL Slorth 0.891938 View
ENSG00000096384 HSP90AB1 ENSG00000126934 MAP2K2 H. sapiens SSL Slorth 0.89187 View
ENSG00000126934 MAP2K2 ENSG00000187608 ISG15 H. sapiens SSL Slorth 0.891796 View
ENSG00000126934 MAP2K2 ENSG00000283094 PTEN H. sapiens SSL Slorth 0.891501 View
ENSG00000126934 MAP2K2 ENSG00000169045 HNRNPH1 H. sapiens SSL Slorth 0.890919 View
ENSG00000126934 MAP2K2 ENSG00000158402 CDC25C H. sapiens SSL Slorth 0.889186 View
ENSG00000070831 CDC42 ENSG00000126934 MAP2K2 H. sapiens SSL Slorth 0.888922 View
ENSG00000069869 NEDD4 ENSG00000126934 MAP2K2 H. sapiens SSL Slorth 0.888353 View
ENSG00000036257 CUL3 ENSG00000126934 MAP2K2 H. sapiens SSL Slorth 0.887171 View
ENSG00000108424 KPNB1 ENSG00000126934 MAP2K2 H. sapiens SSL Slorth 0.886923 View
ENSG00000113721 PDGFRB ENSG00000126934 MAP2K2 H. sapiens SSL Slorth 0.886107 View
ENSG00000126934 MAP2K2 ENSG00000127445 PIN1 H. sapiens SSL Slorth 0.886103 View
ENSG00000105974 CAV1 ENSG00000126934 MAP2K2 H. sapiens SSL Slorth 0.88239 View
ENSG00000073111 MCM2 ENSG00000126934 MAP2K2 H. sapiens SSL Slorth 0.880067 View
ENSG00000123124 WWP1 ENSG00000126934 MAP2K2 H. sapiens SSL Slorth 0.878826 View
ENSG00000126934 MAP2K2 ENSG00000185359 HGS H. sapiens SSL Slorth 0.878409 View
ENSG00000126261 UBA2 ENSG00000126934 MAP2K2 H. sapiens SSL Slorth 0.878072 View
ENSG00000126934 MAP2K2 ENSG00000143190 POU2F1 H. sapiens SSL Slorth 0.877647 View
ENSG00000117133 RPF1 ENSG00000126934 MAP2K2 H. sapiens SSL Slorth 0.877298 View
ENSG00000126934 MAP2K2 ENSG00000129152 MYOD1 H. sapiens SSL Slorth 0.876306 View
ENSG00000117676 RPS6KA1 ENSG00000126934 MAP2K2 H. sapiens SSL Slorth 0.874595 View
ENSG00000280548 FBL ENSG00000126934 MAP2K2 H. sapiens SSL Slorth 0.873961 View
ENSG00000100028 SNRPD3 ENSG00000126934 MAP2K2 H. sapiens SSL Slorth 0.873407 View
ENSG00000078747 ITCH ENSG00000126934 MAP2K2 H. sapiens SSL Slorth 0.871328 View
ENSG00000126934 MAP2K2 ENSG00000136450 SRSF1 H. sapiens SSL Slorth 0.871266 View
ENSG00000126934 MAP2K2 ENSG00000169750 RAC3 H. sapiens SSL Slorth 0.87059 View
ENSG00000049759 NEDD4L ENSG00000126934 MAP2K2 H. sapiens SSL Slorth 0.869608 View
ENSG00000079999 KEAP1 ENSG00000126934 MAP2K2 H. sapiens SSL Slorth 0.867719 View
ENSG00000114767 RRP9 ENSG00000126934 MAP2K2 H. sapiens SSL Slorth 0.866887 View
ENSG00000058729 RIOK2 ENSG00000126934 MAP2K2 H. sapiens SSL Slorth 0.859751 View
ENSG00000103194 USP10 ENSG00000126934 MAP2K2 H. sapiens SSL Slorth 0.858635 View
ENSG00000114166 KAT2B ENSG00000126934 MAP2K2 H. sapiens SSL Slorth 0.858377 View
ENSG00000112118 MCM3 ENSG00000126934 MAP2K2 H. sapiens SSL Slorth 0.857791 View
ENSG00000126934 MAP2K2 ENSG00000138069 RAB1A H. sapiens SSL Slorth 0.857244 View
ENSG00000126934 MAP2K2 ENSG00000164885 CDK5 H. sapiens SSL Slorth 0.855036 View
ENSG00000117399 CDC20 ENSG00000126934 MAP2K2 H. sapiens SSL Slorth 0.854918 View
ENSG00000082898 XPO1 ENSG00000126934 MAP2K2 H. sapiens SSL Slorth 0.852903 View