MAP2K2

ENSG00000126934 - H. sapiens

Pathways

Go term Description
GO:0004674 protein serine/threonine kinase activity
GO:0004702 signal transducer, downstream of receptor, with serine/threonine kinase activity
GO:0004708 MAP kinase kinase activity
GO:0004712 protein serine/threonine/tyrosine kinase activity
GO:0004713 protein tyrosine kinase activity
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0030165 PDZ domain binding
GO:0043539 protein serine/threonine kinase activator activity
GO:0046872 metal ion binding
GO:0097110 scaffold protein binding

Drugs

Drug name Description
TRAMETINIB Dual specificity mitogen-activated protein kinase kinase 2 inhibitor

Diseases

Disease Name
NSCLC
melanoma

Orthologs

Gene Organism
PBS2 S. cerevisiae
mek-2 C. elegans
Dsor1 D. melanogaster

Related Interactions

Gene ID A Gene Name A Gene ID B Gene Symbol B Organism Source Score?
ENSG00000126934 MAP2K2 ENSG00000221983 UBA52 H. sapiens SDL Slorth 0.926326 View
ENSG00000121022 COPS5 ENSG00000126934 MAP2K2 H. sapiens SDL Slorth 0.926287 View
ENSG00000109971 HSPA8 ENSG00000126934 MAP2K2 H. sapiens SSL Slorth 0.925926 View
ENSG00000071082 RPL31 ENSG00000126934 MAP2K2 H. sapiens SDL Slorth 0.925875 View
ENSG00000100906 NFKBIA ENSG00000126934 MAP2K2 H. sapiens SSL Slorth 0.925303 View
ENSG00000072310 SREBF1 ENSG00000126934 MAP2K2 H. sapiens SDL Slorth 0.924547 View
ENSG00000062822 POLD1 ENSG00000126934 MAP2K2 H. sapiens SSL Slorth 0.924326 View
ENSG00000114391 RPL24 ENSG00000126934 MAP2K2 H. sapiens SDL Slorth 0.924217 View
ENSG00000105640 RPL18A ENSG00000126934 MAP2K2 H. sapiens SDL Slorth 0.923317 View
ENSG00000122026 RPL21 ENSG00000126934 MAP2K2 H. sapiens SDL Slorth 0.922849 View
ENSG00000110092 CCND1 ENSG00000126934 MAP2K2 H. sapiens SSL Slorth 0.921835 View
ENSG00000100387 RBX1 ENSG00000126934 MAP2K2 H. sapiens SDL Slorth 0.921672 View
ENSG00000004975 DVL2 ENSG00000126934 MAP2K2 H. sapiens SDL Slorth 0.921654 View
ENSG00000116251 RPL22 ENSG00000126934 MAP2K2 H. sapiens SDL Slorth 0.920723 View
ENSG00000126934 MAP2K2 ENSG00000143106 PSMA5 H. sapiens SDL Slorth 0.92059 View
ENSG00000078140 UBE2K ENSG00000126934 MAP2K2 H. sapiens SSL Slorth 0.920453 View
ENSG00000080815 PSEN1 ENSG00000126934 MAP2K2 H. sapiens SSL Slorth 0.920429 View
ENSG00000077522 ACTN2 ENSG00000126934 MAP2K2 H. sapiens SDL Slorth 0.918992 View
ENSG00000105401 CDC37 ENSG00000126934 MAP2K2 H. sapiens SDL Slorth 0.918634 View
ENSG00000107404 DVL1 ENSG00000126934 MAP2K2 H. sapiens SDL Slorth 0.918005 View
ENSG00000126934 MAP2K2 ENSG00000149273 RPS3 H. sapiens SDL Slorth 0.916691 View
ENSG00000039068 CDH1 ENSG00000126934 MAP2K2 H. sapiens SDL Slorth 0.913174 View
ENSG00000067560 RHOA ENSG00000126934 MAP2K2 H. sapiens SSL Slorth 0.912864 View
ENSG00000109320 NFKB1 ENSG00000126934 MAP2K2 H. sapiens SSL Slorth 0.912448 View
ENSG00000126934 MAP2K2 ENSG00000136930 PSMB7 H. sapiens SDL Slorth 0.911815 View
ENSG00000124614 RPS10 ENSG00000126934 MAP2K2 H. sapiens SDL Slorth 0.909619 View
ENSG00000126934 MAP2K2 ENSG00000142534 RPS11 H. sapiens SDL Slorth 0.909141 View
ENSG00000070010 UFD1L ENSG00000126934 MAP2K2 H. sapiens SSL Slorth 0.909051 View
ENSG00000096717 SIRT1 ENSG00000126934 MAP2K2 H. sapiens SDL Slorth 0.90683 View
ENSG00000075624 ACTB ENSG00000126934 MAP2K2 H. sapiens SSL Slorth 0.906313 View
ENSG00000082898 XPO1 ENSG00000126934 MAP2K2 H. sapiens SDL Slorth 0.905575 View
ENSG00000116473 RAP1A ENSG00000126934 MAP2K2 H. sapiens SDL Slorth 0.903994 View
ENSG00000126934 MAP2K2 ENSG00000131759 RARA H. sapiens SDL Slorth 0.903798 View
ENSG00000126934 MAP2K2 ENSG00000168028 RPSA H. sapiens SDL Slorth 0.902496 View
ENSG00000101361 NOP56 ENSG00000126934 MAP2K2 H. sapiens SDL Slorth 0.900986 View
ENSG00000126934 MAP2K2 ENSG00000137818 RPLP1 H. sapiens SDL Slorth 0.900715 View
ENSG00000126934 MAP2K2 ENSG00000145604 SKP2 H. sapiens SDL Slorth 0.900562 View
ENSG00000109670 FBXW7 ENSG00000126934 MAP2K2 H. sapiens SDL Slorth 0.900521 View
ENSG00000078747 ITCH ENSG00000126934 MAP2K2 H. sapiens SDL Slorth 0.900163 View
ENSG00000110107 PRPF19 ENSG00000126934 MAP2K2 H. sapiens SSL Slorth 0.900032 View