JAK2

ENSG00000096968 - H. sapiens

Pathways

Go term Description
GO:0004672 protein kinase activity
GO:0004713 protein tyrosine kinase activity
GO:0004715 non-membrane spanning protein tyrosine kinase activity
GO:0005088 Ras guanyl-nucleotide exchange factor activity
GO:0005102 receptor binding
GO:0005131 growth hormone receptor binding
GO:0005143 interleukin-12 receptor binding
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0008022 protein C-terminus binding
GO:0019901 protein kinase binding
GO:0020037 heme binding
GO:0031702 type 1 angiotensin receptor binding
GO:0033130 acetylcholine receptor binding
GO:0035401 histone kinase activity (H3-Y41 specific)
GO:0042169 SH2 domain binding
GO:0042393 histone binding
GO:0043548 phosphatidylinositol 3-kinase binding
GO:0043560 insulin receptor substrate binding
GO:0046872 metal ion binding
GO:0051428 peptide hormone receptor binding

Drugs

Drug name Description
RUXOLITINIB Tyrosine-protein kinase JAK2 inhibitor
TOFACITINIB Janus Kinase (JAK) inhibitor

Diseases

Disease Name
ALL
AML
MPN
CML

Orthologs

Gene Organism
hop D. melanogaster

Related Interactions

Gene ID A Gene Name A Gene ID B Gene Symbol B Organism Source Score?
ENSG00000096968 JAK2 ENSG00000166483 WEE1 H. sapiens SDL Slorth 0.91703 View
ENSG00000096968 JAK2 ENSG00000103363 TCEB2 H. sapiens SSL Slorth 0.917006 View
ENSG00000096968 JAK2 ENSG00000171634 BPTF H. sapiens SDL Slorth 0.916976 View
ENSG00000096968 JAK2 ENSG00000157873 TNFRSF14 H. sapiens SDL Slorth 0.916936 View
ENSG00000096968 JAK2 ENSG00000175766 EIF4E1B H. sapiens SDL Slorth 0.91692 View
ENSG00000096968 JAK2 ENSG00000188996 HUS1B H. sapiens SDL Slorth 0.916913 View
ENSG00000096968 JAK2 ENSG00000198561 CTNND1 H. sapiens SDL Slorth 0.916788 View
ENSG00000096968 JAK2 ENSG00000103479 RBL2 H. sapiens SDL Slorth 0.916573 View
ENSG00000096968 JAK2 ENSG00000097007 ABL1 H. sapiens SDL Slorth 0.916557 View
ENSG00000096968 JAK2 ENSG00000130402 ACTN4 H. sapiens SDL Slorth 0.916514 View
ENSG00000096968 JAK2 ENSG00000102554 KLF5 H. sapiens SSL Slorth 0.916481 View
ENSG00000096968 JAK2 ENSG00000166949 SMAD3 H. sapiens SDL Slorth 0.916285 View
ENSG00000096968 JAK2 ENSG00000114867 EIF4G1 H. sapiens SDL Slorth 0.916114 View
ENSG00000096968 JAK2 ENSG00000183207 RUVBL2 H. sapiens SSL Slorth 0.91609 View
ENSG00000096968 JAK2 ENSG00000154767 XPC H. sapiens SSL Slorth 0.916088 View
ENSG00000096968 JAK2 ENSG00000144554 FANCD2 H. sapiens SSL Slorth 0.916076 View
ENSG00000029534 ANK1 ENSG00000096968 JAK2 H. sapiens SDL Slorth 0.915967 View
ENSG00000096968 JAK2 ENSG00000136238 RAC1 H. sapiens SDL Slorth 0.915906 View
ENSG00000096968 JAK2 ENSG00000170035 UBE2E3 H. sapiens SSL Slorth 0.915905 View
ENSG00000096968 JAK2 ENSG00000140464 PML H. sapiens SSL Slorth 0.91587 View
ENSG00000096968 JAK2 ENSG00000168092 PAFAH1B2 H. sapiens SDL Slorth 0.915865 View
ENSG00000096968 JAK2 ENSG00000178573 MAF H. sapiens SDL Slorth 0.915738 View
ENSG00000079134 THOC1 ENSG00000096968 JAK2 H. sapiens SSL Slorth 0.915665 View
ENSG00000096968 JAK2 ENSG00000170144 HNRNPA3 H. sapiens SSL Slorth 0.915373 View
ENSG00000096968 JAK2 ENSG00000175592 FOSL1 H. sapiens SSL Slorth 0.915237 View
ENSG00000096968 JAK2 ENSG00000100462 PRMT5 H. sapiens SDL Slorth 0.915216 View
ENSG00000096968 JAK2 ENSG00000104320 NBN H. sapiens SSL Slorth 0.91517 View
ENSG00000096968 JAK2 ENSG00000130119 GNL3L H. sapiens SSL Slorth 0.915079 View
ENSG00000096968 JAK2 ENSG00000122692 SMU1 H. sapiens SDL Slorth 0.915044 View
ENSG00000096968 JAK2 ENSG00000114867 EIF4G1 H. sapiens SSL Slorth 0.914976 View
ENSG00000096968 JAK2 ENSG00000101421 CHMP4B H. sapiens SDL Slorth 0.914904 View
ENSG00000096968 JAK2 ENSG00000198947 DMD H. sapiens SDL Slorth 0.914857 View
ENSG00000096968 JAK2 ENSG00000107485 GATA3 H. sapiens SSL Slorth 0.914788 View
ENSG00000096968 JAK2 ENSG00000114125 RNF7 H. sapiens SDL Slorth 0.914678 View
ENSG00000096968 JAK2 ENSG00000101266 CSNK2A1 H. sapiens SDL Slorth 0.914666 View
ENSG00000096968 JAK2 ENSG00000168066 SF1 H. sapiens SSL Slorth 0.914614 View
ENSG00000096968 JAK2 ENSG00000172936 MYD88 H. sapiens SSL Slorth 0.914588 View
ENSG00000096968 JAK2 ENSG00000105443 CYTH2 H. sapiens SDL Slorth 0.914477 View
ENSG00000096968 JAK2 ENSG00000103496 STX4 H. sapiens SDL Slorth 0.914412 View
ENSG00000096968 JAK2 ENSG00000197892 KIF13B H. sapiens SDL Slorth 0.91433 View