JAK2

ENSG00000096968 - H. sapiens

Pathways

Go term Description
GO:0004672 protein kinase activity
GO:0004713 protein tyrosine kinase activity
GO:0004715 non-membrane spanning protein tyrosine kinase activity
GO:0005088 Ras guanyl-nucleotide exchange factor activity
GO:0005102 receptor binding
GO:0005131 growth hormone receptor binding
GO:0005143 interleukin-12 receptor binding
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0008022 protein C-terminus binding
GO:0019901 protein kinase binding
GO:0020037 heme binding
GO:0031702 type 1 angiotensin receptor binding
GO:0033130 acetylcholine receptor binding
GO:0035401 histone kinase activity (H3-Y41 specific)
GO:0042169 SH2 domain binding
GO:0042393 histone binding
GO:0043548 phosphatidylinositol 3-kinase binding
GO:0043560 insulin receptor substrate binding
GO:0046872 metal ion binding
GO:0051428 peptide hormone receptor binding

Drugs

Drug name Description
RUXOLITINIB Tyrosine-protein kinase JAK2 inhibitor
TOFACITINIB Janus Kinase (JAK) inhibitor

Diseases

Disease Name
ALL
AML
MPN
CML

Orthologs

Gene Organism
hop D. melanogaster

Related Interactions

Gene ID A Gene Name A Gene ID B Gene Symbol B Organism Source Score?
ENSG00000096968 JAK2 ENSG00000128245 YWHAH H. sapiens SSL Slorth 0.919661 View
ENSG00000096968 JAK2 ENSG00000107485 GATA3 H. sapiens SDL Slorth 0.919477 View
ENSG00000096968 JAK2 ENSG00000135341 MAP3K7 H. sapiens SSL Slorth 0.919446 View
ENSG00000096968 JAK2 ENSG00000173039 RELA H. sapiens SSL Slorth 0.919227 View
ENSG00000096968 JAK2 ENSG00000130956 HABP4 H. sapiens SDL Slorth 0.919186 View
ENSG00000096968 JAK2 ENSG00000169398 PTK2 H. sapiens SSL Slorth 0.919136 View
ENSG00000096968 JAK2 ENSG00000099875 MKNK2 H. sapiens SDL Slorth 0.919104 View
ENSG00000096968 JAK2 ENSG00000108312 UBTF H. sapiens SSL Slorth 0.91909 View
ENSG00000096968 JAK2 ENSG00000105254 TBCB H. sapiens SSL Slorth 0.918728 View
ENSG00000002016 RAD52 ENSG00000096968 JAK2 H. sapiens SSL Slorth 0.918623 View
ENSG00000096968 JAK2 ENSG00000169032 MAP2K1 H. sapiens SSL Slorth 0.918595 View
ENSG00000096968 JAK2 ENSG00000113712 CSNK1A1 H. sapiens SSL Slorth 0.918542 View
ENSG00000096968 JAK2 ENSG00000111424 VDR H. sapiens SDL Slorth 0.918524 View
ENSG00000096968 JAK2 ENSG00000104408 EIF3E H. sapiens SSL Slorth 0.918413 View
ENSG00000096968 JAK2 ENSG00000198836 OPA1 H. sapiens SSL Slorth 0.918373 View
ENSG00000096968 JAK2 ENSG00000182578 CSF1R H. sapiens SDL Slorth 0.918272 View
ENSG00000096968 JAK2 ENSG00000164109 MAD2L1 H. sapiens SSL Slorth 0.918216 View
ENSG00000072401 UBE2D1 ENSG00000096968 JAK2 H. sapiens SSL Slorth 0.918206 View
ENSG00000096968 JAK2 ENSG00000159259 CHAF1B H. sapiens SDL Slorth 0.918035 View
ENSG00000096968 JAK2 ENSG00000127511 SIN3B H. sapiens SDL Slorth 0.917961 View
ENSG00000096968 JAK2 ENSG00000185345 PARK2 H. sapiens SSL Slorth 0.917956 View
ENSG00000096968 JAK2 ENSG00000177606 JUN H. sapiens SSL Slorth 0.917905 View
ENSG00000096968 JAK2 ENSG00000196396 PTPN1 H. sapiens SDL Slorth 0.917892 View
ENSG00000096968 JAK2 ENSG00000132155 RAF1 H. sapiens SDL Slorth 0.917771 View
ENSG00000096968 JAK2 ENSG00000109320 NFKB1 H. sapiens SDL Slorth 0.917743 View
ENSG00000096968 JAK2 ENSG00000124486 USP9X H. sapiens SSL Slorth 0.917683 View
ENSG00000096968 JAK2 ENSG00000160789 LMNA H. sapiens SDL Slorth 0.917563 View
ENSG00000096968 JAK2 ENSG00000103363 TCEB2 H. sapiens SDL Slorth 0.917448 View
ENSG00000096968 JAK2 ENSG00000154997 SEPT14 H. sapiens SDL Slorth 0.917378 View
ENSG00000096968 JAK2 ENSG00000159692 CTBP1 H. sapiens SDL Slorth 0.917376 View
ENSG00000096968 JAK2 ENSG00000107581 EIF3A H. sapiens SSL Slorth 0.917347 View
ENSG00000053900 ANAPC4 ENSG00000096968 JAK2 H. sapiens SSL Slorth 0.917319 View
ENSG00000096968 JAK2 ENSG00000145386 CCNA2 H. sapiens SDL Slorth 0.917286 View
ENSG00000096968 JAK2 ENSG00000108953 YWHAE H. sapiens SDL Slorth 0.917261 View
ENSG00000090372 STRN4 ENSG00000096968 JAK2 H. sapiens SSL Slorth 0.917218 View
ENSG00000096968 JAK2 ENSG00000160803 UBQLN4 H. sapiens SSL Slorth 0.917183 View
ENSG00000096968 JAK2 ENSG00000141968 VAV1 H. sapiens SDL Slorth 0.917182 View
ENSG00000096968 JAK2 ENSG00000166226 CCT2 H. sapiens SSL Slorth 0.917181 View
ENSG00000096968 JAK2 ENSG00000109519 GRPEL1 H. sapiens SDL Slorth 0.917095 View
ENSG00000070831 CDC42 ENSG00000096968 JAK2 H. sapiens SSL Slorth 0.917073 View