HIF1A - ERBB2

H. sapiens

SSL interaction

Identifiers

Gene Name	Gene ID	Diseases	Drugs	GO terms	Orthologs
HIF1A	ENSG00000100644	endometrioid carcinoma glioblastoma colorectal renal lung pancreatic	No drugs in record	transcription factor activity, transcription factor binding transcription factor activity, RNA polymerase II transcription factor binding transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding transcription factor activity, sequence-specific DNA binding transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding protein binding transcription factor binding enzyme binding protein kinase binding ubiquitin protein ligase binding histone acetyltransferase binding nuclear hormone receptor binding histone deacetylase binding protein heterodimerization activity Hsp90 protein binding sequence-specific DNA binding	hif-1 (C. elegans)
ERBB2	ENSG00000141736	breast ovarian other tumour types NSCLC gastric	AFATINIB LAPATINIB PERTUZUMAB TRASTUZUMAB TRASTUZUMAB EMTANSINE VANDETANIB	RNA polymerase I core binding protein tyrosine kinase activity transmembrane receptor protein tyrosine kinase activity signal transducer, downstream of receptor, with protein tyrosine kinase activity transmembrane signaling receptor activity Ras guanyl-nucleotide exchange factor activity protein binding ATP binding protein C-terminus binding protein phosphatase binding identical protein binding ErbB-3 class receptor binding phosphatidylinositol-4,5-bisphosphate 3-kinase activity protein heterodimerization activity protein dimerization activity growth factor binding	let-23 (C. elegans) Egfr (D. melanogaster)