KDR - SMAD4

H. sapiens

SSL interaction

Identifiers

Gene Name	Gene ID	Diseases	Drugs	GO terms	Orthologs
KDR	ENSG00000128052	NSCLC angiosarcoma melanoma	AXITINIB CABOZANTINIB LENVATINIB NINTEDANIB PAZOPANIB PONATINIB RAMUCIRUMAB REGORAFENIB SORAFENIB SUNITINIB VANDETANIB	protein tyrosine kinase activity transmembrane receptor protein tyrosine kinase activity signal transducer, downstream of receptor, with protein tyrosine kinase activity vascular endothelial growth factor-activated receptor activity integrin binding protein binding ATP binding growth factor binding Hsp90 protein binding	Pvr (D. melanogaster)
SMAD4	ENSG00000141646	colorectal pancreatic small intestine gastrointestinal polyp	No drugs in record	RNA polymerase II core promoter proximal region sequence-specific DNA binding core promoter proximal region sequence-specific DNA binding transcription factor activity, RNA polymerase II transcription factor binding transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding RNA polymerase II transcription factor binding chromatin binding protein binding collagen binding transforming growth factor beta receptor, common-partner cytoplasmic mediator activity identical protein binding protein homodimerization activity transcription regulatory region DNA binding metal ion binding protein heterodimerization activity I-SMAD binding R-SMAD binding transcription factor activity, protein binding DNA binding transcription factor activity, sequence-specific DNA binding sequence-specific DNA binding	Med (D. melanogaster)