ADAM17 - HDAC2

SDL interaction

Gene Name	Gene ID	Diseases	Drugs	GO terms	Orthologs
ADAM17	ENSG00000151694	No diseases in record	No drugs in record	metalloendopeptidase activity Notch binding interleukin-6 receptor binding integrin binding protein binding metallopeptidase activity SH3 domain binding PDZ domain binding metal ion binding	Tace (D. melanogaster)
HDAC2	ENSG00000196591	No diseases in record	BELINOSTAT PANOBINOSTAT ROMIDEPSIN VORINOSTAT	core promoter binding RNA polymerase II repressing transcription factor binding chromatin binding histone deacetylase activity protein binding transcription factor binding deacetylase activity enzyme binding heat shock protein binding NAD-dependent histone deacetylase activity (H3-K14 specific) protein deacetylase activity sequence-specific DNA binding NF-kappaB binding RNA polymerase II core promoter proximal region sequence-specific DNA binding RNA polymerase II distal enhancer sequence-specific DNA binding nucleosomal DNA binding	RPD3 (S. cerevisiae) hda-1 (C. elegans) hda-3 (C. elegans)