HSP90AB1 - TOP2A

SDL interaction

Gene Name	Gene ID	Diseases	Drugs	GO terms	Orthologs
HSP90AB1	ENSG00000096384	NHL	No drugs in record	glycoprotein binding UTP binding CTP binding double-stranded RNA binding protein binding ATP binding GTP binding drug binding sulfonylurea receptor binding protein kinase regulator activity kinase binding protein kinase binding MHC class II protein complex binding nitric-oxide synthase regulator activity TPR domain binding heat shock protein binding dATP binding histone deacetylase binding ion channel binding protein dimerization activity unfolded protein binding cadherin binding involved in cell-cell adhesion histone methyltransferase binding	HSC82 (S. cerevisiae) HSP82 (S. cerevisiae) daf-21 (C. elegans) Hsp83 (D. melanogaster)
TOP2A	ENSG00000131747	No diseases in record	DAUNORUBICIN DOXORUBICIN EPIRUBICIN ETOPOSIDE ETOPOSIDE PHOSPHATE IDARUBICIN MITOXANTRONE PODOFILOX TENIPOSIDE VALRUBICIN	magnesium ion binding DNA binding chromatin binding DNA topoisomerase type II (ATP-hydrolyzing) activity protein kinase C binding protein binding ATP binding protein C-terminus binding DNA-dependent ATPase activity drug binding DNA binding, bending enzyme binding protein homodimerization activity histone deacetylase binding ubiquitin binding protein heterodimerization activity	TOP2 (S. cerevisiae) cin-4 (C. elegans) top-2 (C. elegans)