JAK2 - USP8

SDL interaction

Gene Name	Gene ID	Diseases	Drugs	GO terms	Orthologs
JAK2	ENSG00000096968	ALL AML MPN CML	RUXOLITINIB TOFACITINIB	protein kinase activity protein tyrosine kinase activity non-membrane spanning protein tyrosine kinase activity Ras guanyl-nucleotide exchange factor activity receptor binding growth hormone receptor binding interleukin-12 receptor binding protein binding ATP binding protein C-terminus binding protein kinase binding heme binding type 1 angiotensin receptor binding acetylcholine receptor binding histone kinase activity (H3-Y41 specific) SH2 domain binding histone binding phosphatidylinositol 3-kinase binding insulin receptor substrate binding metal ion binding peptide hormone receptor binding	hop (D. melanogaster)
USP8	ENSG00000138592	corticotroph adenoma	No drugs in record	cysteine-type endopeptidase activity thiol-dependent ubiquitin-specific protease activity protein binding SH3 domain binding cadherin binding involved in cell-cell adhesion	DOA4 (S. cerevisiae) UBP5 (S. cerevisiae)