MCM2 - SIRT1

SDL interaction

Gene Name	Gene ID	Diseases	Drugs	GO terms	Orthologs
MCM2	ENSG00000073111	No diseases in record	No drugs in record	DNA binding DNA helicase activity DNA replication origin binding protein binding ATP binding enzyme binding histone binding metal ion binding chromatin binding single-stranded DNA-dependent ATP-dependent DNA helicase activity nucleotide binding hydrolase activity helicase activity single-stranded DNA binding 3'-5' DNA helicase activity ATP-dependent DNA helicase activity	MCM2 (S. cerevisiae) Mcm2 (D. melanogaster)
SIRT1	ENSG00000096717	No diseases in record	No drugs in record	core promoter sequence-specific DNA binding p53 binding transcription corepressor activity histone deacetylase activity protein binding protein C-terminus binding transcription factor binding NAD-dependent histone deacetylase activity deacetylase activity enzyme binding protein deacetylase activity NAD-dependent protein deacetylase activity nuclear hormone receptor binding histone binding identical protein binding HLH domain binding bHLH transcription factor binding metal ion binding NAD-dependent histone deacetylase activity (H3-K9 specific) mitogen-activated protein kinase binding NAD+ binding keratin filament binding NAD+ ADP-ribosyltransferase activity	HST1 (S. cerevisiae) SIR2 (S. cerevisiae) sir-2.1 (C. elegans)