NEDD4 - POLE

SSL interaction

Gene Name	Gene ID	Diseases	Drugs	GO terms	Orthologs
NEDD4	ENSG00000069869	No diseases in record	No drugs in record	protein binding sodium channel inhibitor activity protein domain specific binding beta-2 adrenergic receptor binding ionotropic glutamate receptor binding ubiquitin binding phosphoserine residue binding phosphothreonine residue binding ubiquitin protein ligase activity RNA polymerase binding proline-rich region binding ubiquitin-protein transferase activity Notch binding myosin binding	RSP5 (S. cerevisiae) Nedd4 (D. melanogaster)
POLE	ENSG00000177084	colorectal carcinoma endometrioid carcinoma stomach carcinoma skin cancer colorectal cancer susceptibility	CLOFARABINE CYTARABINE FLUDARABINE PHOSPHATE GEMCITABINE	nucleotide binding DNA binding chromatin binding DNA-directed DNA polymerase activity zinc ion binding single-stranded DNA 3'-5' exodeoxyribonuclease activity 4 iron, 4 sulfur cluster binding	POL2 (S. cerevisiae) pole-1 (C. elegans) DNApol-epsilon255 (D. melanogaster)