JAK2 - CALR

SSL interaction

Gene Name	Gene ID	Diseases	Drugs	GO terms	Orthologs
JAK2	ENSG00000096968	ALL AML MPN CML	RUXOLITINIB TOFACITINIB	protein kinase activity protein tyrosine kinase activity non-membrane spanning protein tyrosine kinase activity Ras guanyl-nucleotide exchange factor activity receptor binding growth hormone receptor binding interleukin-12 receptor binding protein binding ATP binding protein C-terminus binding protein kinase binding heme binding type 1 angiotensin receptor binding acetylcholine receptor binding histone kinase activity (H3-Y41 specific) SH2 domain binding histone binding phosphatidylinositol 3-kinase binding insulin receptor substrate binding metal ion binding peptide hormone receptor binding	hop (D. melanogaster)
CALR	ENSG00000179218	MPN MDS	No drugs in record	complement component C1q binding glycoprotein binding DNA binding mRNA binding integrin binding iron ion binding calcium ion binding protein binding zinc ion binding carbohydrate binding ubiquitin protein ligase binding peptide binding hormone binding protein binding involved in protein folding androgen receptor binding unfolded protein binding chaperone binding	CNE1 (S. cerevisiae) crt-1 (C. elegans)