JAK2 - BUB1B

SSL interaction

Gene Name	Gene ID	Diseases	Drugs	GO terms	Orthologs
JAK2	ENSG00000096968	ALL AML MPN CML	RUXOLITINIB TOFACITINIB	protein kinase activity protein tyrosine kinase activity non-membrane spanning protein tyrosine kinase activity Ras guanyl-nucleotide exchange factor activity receptor binding growth hormone receptor binding interleukin-12 receptor binding protein binding ATP binding protein C-terminus binding protein kinase binding heme binding type 1 angiotensin receptor binding acetylcholine receptor binding histone kinase activity (H3-Y41 specific) SH2 domain binding histone binding phosphatidylinositol 3-kinase binding insulin receptor substrate binding metal ion binding peptide hormone receptor binding	hop (D. melanogaster)
BUB1B	ENSG00000156970	rhabdomyosarcoma	No drugs in record	protein kinase activity protein serine/threonine kinase activity protein binding ATP binding	BUB1 (S. cerevisiae) MAD3 (S. cerevisiae) bub-1 (C. elegans) Bub1 (D. melanogaster) BubR1 (D. melanogaster)