DNM2 - SIRT1

SSL interaction

Gene Name	Gene ID	Diseases	Drugs	GO terms	Orthologs
DNM2	ENSG00000079805	T-ALL	No drugs in record	GTPase activity protein binding GTP binding microtubule binding SH3 domain binding enzyme binding protein kinase binding D2 dopamine receptor binding protein complex binding phosphatidylinositol 3-kinase regulatory subunit binding WW domain binding nitric-oxide synthase binding	VPS1 (S. cerevisiae) dyn-1 (C. elegans) shi (D. melanogaster)
SIRT1	ENSG00000096717	No diseases in record	No drugs in record	core promoter sequence-specific DNA binding p53 binding transcription corepressor activity histone deacetylase activity protein binding protein C-terminus binding transcription factor binding NAD-dependent histone deacetylase activity deacetylase activity enzyme binding protein deacetylase activity NAD-dependent protein deacetylase activity nuclear hormone receptor binding histone binding identical protein binding HLH domain binding bHLH transcription factor binding metal ion binding NAD-dependent histone deacetylase activity (H3-K9 specific) mitogen-activated protein kinase binding NAD+ binding keratin filament binding NAD+ ADP-ribosyltransferase activity	HST1 (S. cerevisiae) SIR2 (S. cerevisiae) sir-2.1 (C. elegans)