TOP1 - LYN

SSL interaction

Gene Name	Gene ID	Diseases	Drugs	GO terms	Orthologs
TOP1	ENSG00000198900	AML*	IRINOTECAN	core promoter sequence-specific DNA binding DNA binding chromatin binding DNA topoisomerase type I activity protein binding isomerase activity DNA topoisomerase activity	TOP1 (S. cerevisiae) top-1 (C. elegans) Top1 (D. melanogaster)
LYN	ENSG00000254087	No diseases in record	BOSUTINIB DASATINIB PONATINIB	protein tyrosine kinase activity non-membrane spanning protein tyrosine kinase activity signal transducer, downstream of receptor, with protein tyrosine kinase activity receptor binding platelet-derived growth factor receptor binding integrin binding protein binding ATP binding SH3 domain binding ubiquitin protein ligase binding gamma-tubulin binding glycosphingolipid binding ion channel binding phosphoprotein binding	Src64B (D. melanogaster)