TOP1 - PGAM5

SSL interaction

Gene Name	Gene ID	Diseases	Drugs	GO terms	Orthologs
TOP1	ENSG00000198900	AML*	IRINOTECAN	core promoter sequence-specific DNA binding DNA binding chromatin binding DNA topoisomerase type I activity protein binding isomerase activity DNA topoisomerase activity	TOP1 (S. cerevisiae) top-1 (C. elegans) Top1 (D. melanogaster)
PGAM5	ENSG00000247077	No diseases in record	No drugs in record	GTPase activator activity signal transducer, downstream of receptor, with serine/threonine phosphatase activity phosphatase activity protein complex binding protein serine/threonine kinase activator activity phosphoprotein phosphatase activity protein serine/threonine phosphatase activity phosphoglycerate mutase activity kinase binding protein binding	Pgam5 (D. melanogaster) Pgam5-2 (D. melanogaster)