RUNX2 - MAP2K1

SSL interaction

Gene Name	Gene ID	Diseases	Drugs	GO terms	Orthologs
RUNX2	ENSG00000124813	No diseases in record	No drugs in record	RNA polymerase II core promoter proximal region sequence-specific DNA binding RNA polymerase II core promoter sequence-specific DNA binding RNA polymerase II transcription factor activity, sequence-specific DNA binding transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding chromatin binding transcription factor activity, sequence-specific DNA binding protein binding ATP binding protein domain specific binding bHLH transcription factor binding repressing transcription factor binding	rnt-1 (C. elegans) run (D. melanogaster) lz (D. melanogaster)
MAP2K1	ENSG00000169032	NSCLC melanoma colorectal	TRAMETINIB	protein kinase activity protein serine/threonine kinase activity signal transducer, downstream of receptor, with serine/threonine kinase activity MAP kinase kinase activity protein serine/threonine/tyrosine kinase activity protein tyrosine kinase activity signal transducer, downstream of receptor, with protein tyrosine phosphatase activity protein binding ATP binding protein C-terminus binding protein kinase binding protein serine/threonine kinase activator activity protein N-terminus binding	PBS2 (S. cerevisiae) mek-2 (C. elegans) Dsor1 (D. melanogaster)