MEN1 - BRAF

SSL interaction

Gene Name	Gene ID	Diseases	Drugs	GO terms	Orthologs
MEN1	ENSG00000133895	parathyroid tumours pancreatic neuroendocrine tumour parathyroid adenoma pituitary adenoma pancreatic islet cell carcinoid	No drugs in record	four-way junction DNA binding Y-form DNA binding chromatin binding double-stranded DNA binding protein binding protein binding, bridging transcription regulatory region DNA binding protein N-terminus binding R-SMAD binding histone-lysine N-methyltransferase activity	Mnn1 (D. melanogaster)
BRAF	ENSG00000157764	melanoma colorectal papillary thyroid borderline ovarian NSCLC cholangiocarcinoma pilocytic astrocytoma Spitzoid tumour pancreas acinar carcinoma melanocytic nevus prostate gastric	DABRAFENIB REGORAFENIB SORAFENIB VEMURAFENIB	protein kinase activity protein serine/threonine kinase activity MAP kinase kinase kinase activity calcium ion binding protein binding ATP binding mitogen-activated protein kinase kinase binding identical protein binding protein heterodimerization activity small GTPase binding	lin-45 (C. elegans)