MAP2K4 - NOTCH1

SSL interaction

Gene Name	Gene ID	Diseases	Drugs	GO terms	Orthologs
MAP2K4	ENSG00000065559	pancreatic breast colorectal	No drugs in record	protein kinase activity signal transducer, downstream of receptor, with serine/threonine kinase activity protein tyrosine kinase activity protein binding ATP binding JUN kinase kinase activity mitogen-activated protein kinase kinase kinase binding	PBS2 (S. cerevisiae) sek-3 (C. elegans) mkk-4 (C. elegans) sek-6 (C. elegans) Mkk4 (D. melanogaster)
NOTCH1	ENSG00000148400	T-ALL breast bladder skin SCC lung SCC head and neck SCC	No drugs in record	core promoter binding transcriptional activator activity, RNA polymerase II transcription factor binding transcription factor activity, sequence-specific DNA binding enzyme inhibitor activity receptor activity Notch binding calcium ion binding protein binding enzyme binding chromatin DNA binding sequence-specific DNA binding protein heterodimerization activity	N (D. melanogaster)