KDM6A - PTEN

SSL interaction

Gene Name	Gene ID	Diseases	Drugs	GO terms	Orthologs
KDM6A	ENSG00000147050	renal cell carcinoma bladder carcinoma oesophageal SCC MM medulloblastoma T-ALL other tumour types	No drugs in record	RNA polymerase II core promoter proximal region sequence-specific DNA binding chromatin DNA binding histone demethylase activity identical protein binding metal ion binding dioxygenase activity histone demethylase activity (H3-K27 specific)	CYC8 (S. cerevisiae) Utx (D. melanogaster)
PTEN	ENSG00000283094	glioma prostate endometrial harmartoma	No drugs in record	magnesium ion binding phosphatidylinositol-3-phosphatase activity phosphoprotein phosphatase activity protein serine/threonine phosphatase activity protein tyrosine phosphatase activity platelet-derived growth factor receptor binding protein binding protein tyrosine/serine/threonine phosphatase activity lipid binding anaphase-promoting complex binding phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity enzyme binding protein kinase binding PDZ domain binding identical protein binding inositol-1,3,4,5-tetrakisphosphate 3-phosphatase activity phosphatidylinositol-3,4-bisphosphate 3-phosphatase activity non-membrane spanning protein tyrosine phosphatase activity actin binding	daf-18 (C. elegans) Pten (D. melanogaster)