MAP2K1

ENSG00000169032 - H. sapiens

Pathways

Go term Description
GO:0004672 protein kinase activity
GO:0004674 protein serine/threonine kinase activity
GO:0004702 signal transducer, downstream of receptor, with serine/threonine kinase activity
GO:0004708 MAP kinase kinase activity
GO:0004712 protein serine/threonine/tyrosine kinase activity
GO:0004713 protein tyrosine kinase activity
GO:0004728 signal transducer, downstream of receptor, with protein tyrosine phosphatase activity
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0008022 protein C-terminus binding
GO:0019901 protein kinase binding
GO:0043539 protein serine/threonine kinase activator activity
GO:0047485 protein N-terminus binding

Drugs

Drug name Description
TRAMETINIB Dual specificity mitogen-activated protein kinase kinase 2 inhibitor

Diseases

Disease Name
NSCLC
melanoma
colorectal

Orthologs

Gene Organism
PBS2 S. cerevisiae
mek-2 C. elegans
Dsor1 D. melanogaster

Related Interactions

Gene ID A Gene Name A Gene ID B Gene Symbol B Organism Source Score?
ENSG00000103035 PSMD7 ENSG00000169032 MAP2K1 H. sapiens SDL Slorth 0.95191 View
ENSG00000148400 NOTCH1 ENSG00000169032 MAP2K1 H. sapiens SDL Slorth 0.951793 View
ENSG00000112592 TBP ENSG00000169032 MAP2K1 H. sapiens SSL Slorth 0.951783 View
ENSG00000101966 XIAP ENSG00000169032 MAP2K1 H. sapiens SDL Slorth 0.951782 View
ENSG00000004700 RECQL ENSG00000169032 MAP2K1 H. sapiens SSL Slorth 0.95174 View
ENSG00000128245 YWHAH ENSG00000169032 MAP2K1 H. sapiens SDL Slorth 0.951348 View
ENSG00000148400 NOTCH1 ENSG00000169032 MAP2K1 H. sapiens SSL Slorth 0.951239 View
ENSG00000109062 SLC9A3R1 ENSG00000169032 MAP2K1 H. sapiens SDL Slorth 0.951083 View
ENSG00000100906 NFKBIA ENSG00000169032 MAP2K1 H. sapiens SDL Slorth 0.950998 View
ENSG00000117676 RPS6KA1 ENSG00000169032 MAP2K1 H. sapiens SDL Slorth 0.950975 View
ENSG00000169032 MAP2K1 ENSG00000182968 SOX1 H. sapiens SDL Slorth 0.950969 View
ENSG00000137693 YAP1 ENSG00000169032 MAP2K1 H. sapiens SDL Slorth 0.950857 View
ENSG00000135446 CDK4 ENSG00000169032 MAP2K1 H. sapiens SSL Slorth 0.95053 View
ENSG00000122406 RPL5 ENSG00000169032 MAP2K1 H. sapiens SDL Slorth 0.950528 View
ENSG00000169032 MAP2K1 ENSG00000185697 MYBL1 H. sapiens SDL Slorth 0.950516 View
ENSG00000076984 MAP2K7 ENSG00000169032 MAP2K1 H. sapiens SDL Slorth 0.950107 View
ENSG00000169032 MAP2K1 ENSG00000185591 SP1 H. sapiens SDL Slorth 0.949986 View
ENSG00000169032 MAP2K1 ENSG00000185022 MAFF H. sapiens SDL Slorth 0.949946 View
ENSG00000073111 MCM2 ENSG00000169032 MAP2K1 H. sapiens SSL Slorth 0.949852 View
ENSG00000097007 ABL1 ENSG00000169032 MAP2K1 H. sapiens SDL Slorth 0.949793 View
ENSG00000110395 CBL ENSG00000169032 MAP2K1 H. sapiens SSL Slorth 0.949778 View
ENSG00000113575 PPP2CA ENSG00000169032 MAP2K1 H. sapiens SSL Slorth 0.949406 View
ENSG00000121774 KHDRBS1 ENSG00000169032 MAP2K1 H. sapiens SSL Slorth 0.949107 View
ENSG00000169032 MAP2K1 ENSG00000198373 WWP2 H. sapiens SDL Slorth 0.948953 View
ENSG00000165731 RET ENSG00000169032 MAP2K1 H. sapiens SDL Slorth 0.94852 View
ENSG00000145604 SKP2 ENSG00000169032 MAP2K1 H. sapiens SDL Slorth 0.948491 View
ENSG00000101412 E2F1 ENSG00000169032 MAP2K1 H. sapiens SSL Slorth 0.948478 View
ENSG00000168148 HIST3H3 ENSG00000169032 MAP2K1 H. sapiens SSL Slorth 0.948414 View
ENSG00000134057 CCNB1 ENSG00000169032 MAP2K1 H. sapiens SSL Slorth 0.948376 View
ENSG00000169032 MAP2K1 ENSG00000172367 PDZD3 H. sapiens SDL Slorth 0.94837 View
ENSG00000136518 ACTL6A ENSG00000169032 MAP2K1 H. sapiens SSL Slorth 0.948347 View
ENSG00000105401 CDC37 ENSG00000169032 MAP2K1 H. sapiens SDL Slorth 0.948325 View
ENSG00000142208 AKT1 ENSG00000169032 MAP2K1 H. sapiens SSL Slorth 0.94813 View
ENSG00000080815 PSEN1 ENSG00000169032 MAP2K1 H. sapiens SSL Slorth 0.947949 View
ENSG00000159377 PSMB4 ENSG00000169032 MAP2K1 H. sapiens SDL Slorth 0.947926 View
ENSG00000117399 CDC20 ENSG00000169032 MAP2K1 H. sapiens SSL Slorth 0.947757 View
ENSG00000150093 ITGB1 ENSG00000169032 MAP2K1 H. sapiens SSL Slorth 0.947353 View
ENSG00000112062 MAPK14 ENSG00000169032 MAP2K1 H. sapiens SSL Slorth 0.947183 View
ENSG00000164924 YWHAZ ENSG00000169032 MAP2K1 H. sapiens SSL Slorth 0.947093 View
ENSG00000138376 BARD1 ENSG00000169032 MAP2K1 H. sapiens SSL Slorth 0.946956 View